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High purity ISRIB CAS NO 1597403-47-8

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  • Supply High Purity ISRIB(trans-isomer) CAS 1597403

    High Purity ISRIB(trans-isomer) CAS 1597403-47-8. In a study published March 29, 2018 in Science, UCSF biochemist Peter Walter, PhD, and structural biologist Adam Frost, MD, PhD, showed that the drug, ISRIB (pronounced “iz-rib”), acts like a molecular staple, pinning together parts of a much larger protein involved in cellular stress.. The researchers hope the finding will help researchers ...

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  • ISRIB (trans-isomer) | CAS:1597403-47-8 | PERK

    ISRIB (trans-isomer)(1597403-47-8) Reference standards for Pharmacological research. ISRIB (trans-isomer) is a potent inhibitor of the integrated stress response (ISR) [1]. …

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  • ISRIB | CAS#:1597403-47-8 | Chemsrc

    Chemsrc provides ISRIB(CAS#:1597403-47-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ISRIB are included as well.

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  • Isrib (trans-isomer) Powder Cas 1597403-47-8 Trans

    Product name ISRIB(trans-isomer) 1597403-47-8 CAS NO. 1597403-47-8 Synonyms ISRIB(trans-isomer) Category Pharmaceutical Intermediates, organic building blocks,Fine Chemicals, chemical intermediate Purity 98% Appearance ISRIB(trans-isomer) 1597403-47-8 powder Shelf life 2 years Usage ISRIB(trans-isomer) 1597403-47-8 is a pharmaceutical intermediate.

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  • CAS No. 1597403-47-8 | Sigma-Aldrich

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  • trans-ISRIB (CAS 1597403-47-8): R&D Systems

    CAS No: 1597403-47-8. The technical data provided above is for guidance only. ... Induced the ISR and added ISRIB (100 and 500nM) overnight. Evaluated p-eif2a (unchanged) and cleaved caspase 3 (increased in a dose-dependent manner with ISRIB. High specific inhibitor. By Anonymous on 11/01/2017

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  • trans-ISRIB Supplier | CAS 1597403-47-8 | Tocris

    Biological Activity. Integrated stress response (ISR) inhibitor; reverses the effects of eIF2 α phosphorylation (IC 50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2 α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro.Displays memory enhancement in hippocampus-dependent spatial …

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  • High Quality Inhibitors Isrib 548470-11-7 /1597403-47

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  • SML0843-25MG | Sigma-Aldrich

    CAS 1597403-47-8 分子式 C22H24Cl2N2O4 分子量 451.34 靶点: PERK; ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).

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  • ISRIB (trans-isomer) | ≥99%(HPLC) | Selleck | PERK ...

    CAS号码 #: 1597403-47-8 (trans-ISRIB)纯度 ≥98% Description: ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. ISRIB reversed the effects of eIF2α phosphorylation with IC50 value of 5 nM.

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  • ISRIB | Integrated stress response inhibitor - Focus ...

    cas no. 1597403-47-8 ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.

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  • ISRIB (trans-isomer), Inhibitor of “Integrated Stress ...

    ISRIB (1597403-47-8) is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC 50 =5 nM. 1 Enhances spatial and fear-associated learning in mice and enhances cognitive function. 1,2 Mechanism of action involves activation of eiF2 β. 3 Suppresses ER stress-induced inflammatory gene expression. 4 Potently attenuates amyloid ...

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  • trans-ISRIB (CAS 1597403-47-8) - Cayman Chemical

    Product Information Molecular Weight: 451.34 Formula: C22H24Cl2N2O4 Purity: ≥98% CAS#: 1597403-47-8 Solubility: DMSO up to 100 mM Chemical Name: N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. Biological Activity: In cells, distinct st

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    trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC 50 = 5 nM in a cell-reporter assay). 1 Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by ...

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  • 2006277-47-8 | Sigma-Aldrich

    Search results for PERK at Sigma-Aldrich. Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis.

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    Factory Supply High Quality ISRIB (trans-isoMer) Powder CAS.1597403-47-8 99% Purity

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    Dylonine Ingredients High Purity Injection, CAS 586-60-7, Safe Ship to USA, CA, Autralia, EU, Russia. ... GMP Manufacturer Sells ISRIB Powder, CAS 1597403-47-8,SMDC 750213 Ingredients USA, Australia, Canada. GMP Manufacturer L-Theanine Powder CAS 3081 …

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    Wuhan HHD ISRIB Quality 99% ISRIB (trans-isomer) Powder CAS 1597403-47-8 Trans Isrib . US 180,00-US 250,00 gram ... High Purity Low Price Sildenafil citrate powder 171599-83-0 raw material

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    2021-2-14 · ISRIB has been licensed by Google's anti-aging research company Calico. ISRIB (whose CAS number is 1597403-47-8) appears to be available at dozens of lab chemical suppliers, 10 mg costing around the 100 mark. And on Alibaba, one wholesaler is selling 1 gram for 100.

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  • PERK | Sigma-Aldrich

    Search results for PERK at Sigma-Aldrich. Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis.

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    Wuhan HHD ISRIB Quality 99% ISRIB (trans-isomer) Powder CAS 1597403-47-8 Trans Isrib . US 180,00-US 250,00 gram ... High Purity Low Price Sildenafil citrate powder 171599-83-0 raw material

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