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    J Ethnopharmacol. 2009 Jul 6;124(1):98-102. Neferine was isolated from green seed embryo of Nelumbo nucifera Gaertn which has been used as an anti-obesity agent in traditional Chinese herbal medicine.

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    Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana.[Pubmed:30897964] J Asian Nat Prod Res. 2019 Mar 21:1-9. One new aporphine named tavoyanine A (1), along with four known aporphines Laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe …

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    J Ethnopharmacol. 2009 Jul 6;124(1):98-102. Neferine was isolated from green seed embryo of Nelumbo nucifera Gaertn which has been used as an anti-obesity agent in traditional Chinese herbal medicine.

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    Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana.[Pubmed:30897964] J Asian Nat Prod Res. 2019 Mar 21:1-9. One new aporphine named tavoyanine A (1), along with four known aporphines Laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe …

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    2021-3-12 · KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-“undruggable” target; however clinically viable inhibitors have yet to be identified. Here, we report efforts to exploit a cryptic pocket (H95/Y96/Q99) we identified in KRASG12C to identify inhibitors ...

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    DMF, reported in chemical databases as both N-1- (CAS 124751-00-4) and N-2-trityl (CAS 133909-99-6), is tritylated at N -2 of tetrazole, which was unambiguously proved by SCXRD [ 24 ]. Molecules ...

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  • Discovery of a Covalent Inhibitor of KRASG12C (AMG

    2021-3-12 · KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-“undruggable” target; however clinically viable inhibitors have yet to be identified. Here, we report efforts to exploit a cryptic pocket (H95/Y96/Q99) we identified in KRASG12C to identify inhibitors ...

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  • (PDF) Synthesis and Physicochemical Characterization

    DMF, reported in chemical databases as both N-1- (CAS 124751-00-4) and N-2-trityl (CAS 133909-99-6), is tritylated at N -2 of tetrazole, which was unambiguously proved by SCXRD [ 24 ]. Molecules ...

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    11 6 1 1001 ± 9.35 288.22 4.6 ± 0.41 6.98 12 6 10 991 ± 8.66 210.48 4.7 ± 0.40 7.14 Baghapour et al. Journal of Environmental Health Science and Engineering 2013, 11 :6 Page 4 of 9

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  • (PDF) Synthesis and Physicochemical Characterization

    DMF, reported in chemical databases as both N-1- (CAS 124751-00-4) and N-2-trityl (CAS 133909-99-6), is tritylated at N -2 of tetrazole, which was unambiguously proved by SCXRD [ 24 ]. Molecules ...

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    2021-3-13 · This Viewpoint describes major advances pertaining to perfunctionalized boron clusters in synthesis and their respective applications. The first portion of this work highlights key synthetic methods, allowing one to access a wide range of polyhedral boranes (B4 and B6–B12 cluster cores) that contain exhaustively functionalized vertices. The second portion of this Viewpoint showcases the ...

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  • 2013 « New Drug Approvals « Page 2

    The filtrate under reduced pressure to recover the solvent (about 50ml), dried over anhydrous methanol residue – petroleum ether (2: 1) and recrystallized to give white crystals of Intermediate V (6.2g, 90.9%), mp 121.1 ~123.6 ° C. Purity 98.6% (HPLC normalization method). Synthesis of tolvaptan: Example 4

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    Exhibit 16: Estimated Energy Sources for the U.S. Pulp and Paper Industry, 1972, 1979, 1990 by percentages Energy source Purchased steam Coal Fuel oil Natural gas Waste wood and wood chips (Hogged fuel) and bark Spent liquor solids Self-generated power 1972 5.4 9.8 22.3 21.5 6.6 33.7 0.6 1979 6.7 9.1 19.1 17.8 9.2 37.3 0.8 1990 7.3 13.7 6.4 16 ...

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